Dennis A Hesselink Selected Research

Tacrolimus (Prograf)

10/2022	Model-Based Tacrolimus Follow-up Dosing in Adult Renal Transplant Recipients: A Simulation Trial.
7/2022	A Population Pharmacokinetic Model of Whole-Blood and Intracellular Tacrolimus in Kidney Transplant Recipients.
1/2021	Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.
1/2020	Serum magnesium, hepatocyte nuclear factor 1β genotype and post-transplant diabetes mellitus: a prospective study.
1/2020	Incidence of end-stage renal disease after heart transplantation and effect of its treatment on survival.
11/2019	High Intrapatient Variability in Tacrolimus Exposure Is Not Associated With Immune-mediated Graft Injury After Liver Transplantation.
3/2018	Improved Glucose Tolerance in a Kidney Transplant Recipient With Type 2 Diabetes Mellitus After Switching From Tacrolimus To Belatacept: A Case Report and Review of Potential Mechanisms.
1/2018	A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation.
6/2017	Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial.
2/2017	Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Starting Dose.

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Dennis A Hesselink Research Topics

Disease

11	Infections 11/2021 - 01/2009
6	Chronic Renal Insufficiency 01/2022 - 09/2005
6	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 09/2016
6	Hypertension (High Blood Pressure) 06/2017 - 01/2011
6	Malaria 09/2016 - 09/2009
5	Proteinuria 01/2022 - 10/2011
5	Diabetes Mellitus 01/2021 - 02/2014
3	Body Weight (Weight, Body) 10/2022 - 01/2018
3	Virus Diseases (Viral Diseases) 01/2021 - 02/2015
3	COVID-19 11/2020 - 01/2020
3	Reperfusion Injury 11/2020 - 06/2013
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2020 - 06/2008
3	Neoplasms (Cancer) 12/2019 - 04/2016
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 06/2022 - 10/2011
2	Inflammation (Inflammations) 11/2021 - 01/2019
2	Brain Death (Brain Dead) 08/2021 - 07/2017
2	Chronic Hepatitis (Chronic Active Hepatitis) 01/2021 - 02/2015
2	Delayed Graft Function 01/2019 - 05/2012
2	Diarrhea 03/2018 - 06/2012
2	Falciparum Malaria (Plasmodium falciparum Malaria) 05/2010 - 04/2010
1	Albuminuria 01/2022
1	Iron Deficiencies 11/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2021
1	Autoimmune Hepatitis 10/2021
1	Renal Insufficiency (Renal Failure) 07/2021
1	Hemophilia A (Haemophilia) 11/2020
1	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2020
1	Guillain-Barre Syndrome 01/2020
1	Glomerulonephritis 01/2020
1	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/2020
1	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2020
1	Melanoma (Melanoma, Malignant) 12/2019
1	Disease Progression 12/2019
1	Viremia 11/2019
1	Heart Failure 01/2019
1	Hyperglycemia 03/2018
1	Nausea 03/2018
1	Type 2 Diabetes Mellitus (MODY) 03/2018
1	Hepatitis E 01/2018
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2018
1	Multiple Sclerosis 01/2018
1	Edema (Dropsy) 06/2017
1	Overweight 02/2017
1	Rheumatoid Arthritis 01/2017
1	Tuberous Sclerosis (Bourneville's Disease) 04/2016

Drug/Important Bio-Agent (IBA)

16	Tacrolimus (Prograf)FDA LinkGeneric 10/2022 - 08/2010
5	Alemtuzumab (Campath)FDA Link 11/2020 - 02/2015
5	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2009
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 06/2012 - 06/2008
3	Ribavirin (Virazole)FDA LinkGeneric 01/2021 - 01/2016
3	CreatinineIBA 09/2016 - 05/2012
3	Cytochrome P-450 CYP3AIBA 09/2014 - 05/2012
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 06/2014
2	EnzymesIBA 06/2018 - 06/2014
2	Abatacept (Orencia)FDA Link 03/2018 - 01/2016
2	Antihypertensive Agents (Antihypertensives)IBA 06/2017 - 01/2011
2	Calcineurin InhibitorsIBA 06/2014 - 08/2010
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 06/2012 - 05/2012
2	SodiumIBA 01/2012 - 05/2010
2	C-Reactive ProteinIBA 01/2012 - 01/2012
2	ProcalcitoninIBA 09/2009 - 01/2009
1	IronIBA 11/2021
1	Neutralizing AntibodiesIBA 11/2021
1	Viral RNAIBA 11/2021
1	dicarboxydine (DCD)IBA 08/2021
1	CholesterolIBA 07/2021
1	MagnesiumIBA 01/2020
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2020
1	Coloring Agents (Dyes)IBA 01/2020
1	Hepatocyte Nuclear FactorsIBA 01/2020
1	Immune Checkpoint InhibitorsIBA 12/2019
1	NivolumabIBA 12/2019
1	Cell-Free Nucleic AcidsIBA 12/2019
1	Everolimus FDA Link 10/2019
1	MTOR InhibitorsIBA 10/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 06/2018
1	Immunosuppressive Agents (Immunosuppressants)IBA 03/2018
1	Insulin (Novolin)FDA Link 03/2018
1	Glucose (Dextrose)FDA LinkGeneric 03/2018
1	Chlorthalidone (Chlortalidone)FDA LinkGeneric 06/2017
1	Amlodipine (Norvasc)FDA LinkGeneric 06/2017
1	LipidsIBA 01/2017
1	CytokinesIBA 01/2017
1	Simvastatin (Zocor)FDA LinkGeneric 01/2017
1	Lipocalin-2IBA 09/2016
1	TOR Serine-Threonine KinasesIBA 04/2016

Therapy/Procedure

11	Kidney Transplantation 06/2022 - 01/2011
10	Transplantation 11/2021 - 08/2010
10	Therapeutics 11/2020 - 04/2010
4	Liver Transplantation 10/2021 - 09/2014
4	Heart-Assist Devices 04/2020 - 01/2018
3	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2020 - 09/2005
2	Heart Transplantation (Grafting, Heart) 01/2020 - 01/2018
1	Blood Component Removal (Apheresis) 06/2022
1	Diet Therapy (Therapy, Diet) 11/2020
1	Conservative Treatment 01/2020
1	Investigational Therapies (Experimental Therapy) 01/2020
1	Peritoneal Dialysis 01/2020
1	Nephrectomy 12/2019